HPV and Other Risk Factors Involved in Pharyngeal Neoplasm—Clinical and Morphopathological Correlations in the Southwestern Region of Romania

Oropharyngeal squamous cell carcinoma (OPSCC) development is strongly associated with risk factors like smoking, chronic alcohol consumption, and the living environment, but also human papilloma virus (HPV) infection, which can trigger cascade cellular changes leading to a neoplastic transformation. The prevalence of these differs among different world regions, prevention, diagnosis, prognosis OPSCC are highly dependent on them. We performed retrospective study 406 patients diagnosed in our region that were classified according tumor type, localization diagnosis stage, demographic characteristics, factors, histological immunohistochemical features. found most men from urban areas smoking habit, while women tonsillar had history alcoholism. During study, we analyzed immunoreactivity against anti-p16 anti-HPV antibodies as markers HPV involvement progression, well correlation percentage intratumoral nuclei immunomarked anti-Ki 67 antibody serial samples. observed Ki67-positive increased proportionally presence HPV; thus, active infection leads an increase rate progression. Our results support implementation strategies for prevention early be starting point future studies aiming at adapting surgical oncological treatment stage better therapeutic results.